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References
- Thalassaemia.Lancet. 2022; 399: 2310-2324
- Global epidemiology of haemoglobin disorders and derived service indicators.Bull World Health Organ. 2008; 86: 480-487
- Genetic variation and susceptibility to infection: the red cell and malaria.Br J Haematol. 2008; 141: 276-286
- The evolving spectrum of the epidemiology of thalassemia.Hematol Oncol Clin North Am. 2018; 32: 165-175
- Changing patterns in the epidemiology of β-thalassemia.Eur J Haematol. 2020; 105: 692-703
- Bacterial cloning of plasmids carrying copies of rabbit globin messenger RNA.Nature. 1976; 260: 221-225
- Structure and function of haemoglobin: III. A three-dimensional fourier synthesis of human deoxyhemoglobin at 5·5 Å resolution.J Mol Biol. 1967; 28: 117-150
- Sickle cell anemia, a molecular disease.Science. 1949; 109: 443
- Gene mutations in human haemoglobin: the chemical difference between normal and sickle cell haemoglobin.Nature. 1957; 180: 326-328
- Fine structure genetic analysis of a beta-globin promoter.Science. 1986; 232: 613-618
- Position-independent, high-level expression of the human beta-globin gene in transgenic mice.Cell. 1987; 51: 975-985
- The structure and evolution of the human beta-globin gene family.Cell. 1980; 21: 653-668
- A review of the molecular genetics of the human alpha-globin gene cluster.Blood. 1989; 73: 1081-1104
- A newly discovered human alpha-globin gene.Blood. 2005; 106: 1466-1472
- Annotation of cis-regulatory elements by identification, subclassification, and functional assessment of multispecies conserved sequences.Proc Natl Acad Sci U S A. 2005; 102: 9830-9835
- Understanding α-globin gene regulation and implications for the treatment of β-thalassemia.Ann N Y Acad Sci. 2016; 1368: 16-24
- Mapping of DNase I-hypersensitive sites in the upstream DNA of human embryonic epsilon-globin gene in K562 leukemia cells.Proc Natl Acad Sci U S A. 1984; 81: 2718-2722
- Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids.Nucleic Acids Res. 1987; 15: 10159-10177
- Transcription complex stability and chromatin dynamics in vivo.Nature. 1995; 377: 209-213
- Looping versus linking: toward a model for long-distance gene activation.Genes Dev. 1999; 13: 2465-2477
- Tissue-specific histone modification and transcription factor binding in alpha globin gene expression.Blood. 2007; 110: 4503-4510
- Chromosome looping at the human alpha-globin locus is mediated via the major upstream regulatory element (HS -40).Blood. 2009; 114: 4253-4260
- Polycomb eviction as a new distant enhancer function.Genes Dev. 2011; 25: 1583-1588
- Reactivation of developmentally silenced globin genes by forced chromatin looping.Cell. 2014; 158: 849-860
- Epigenetic interplay at the β-globin locus.Biochim Biophys Acta Gene Regul Mech. 2017; 1860: 393-404
- Control of globin gene expression during development and erythroid differentiation.Exp Hematol. 2005; 33: 259-271
- Recent progress in understanding and manipulating haemoglobin switching for the haemoglobinopathies.Br J Haematol. 2018; 180: 630-643
- A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.Nat Genet. 2007; 39: 1197-1199
- Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.Proc Natl Acad Sci U S A. 2008; 105: 1620-1625
- Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders.Blood. 2012; 120: 2945-2953
- Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A.Proc Natl Acad Sci U S A. 2013; 110: 6518-6523
- Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.Science. 2008; 322: 1839-1842
- Direct promoter repression by BCL11A controls the fetal to adult hemoglobin switch.Cell. 2018; 173: 430-442.e17
- Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding.Nat Genet. 2018; 50: 498-503
- Transcription factor competition at the γ-globin promoters controls hemoglobin switching.Nat Genet. 2021; 53: 511-520
- An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level.Science. 2013; 342: 253-257
- BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations.J Clin Invest. 2015; 125: 2363-2368
- HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription.Nat Genet. 2022; 54: 1417-1426
- Activation of γ-globin gene expression by GATA1 and NF-Y in hereditary persistence of fetal hemoglobin.Nat Genet. 2021; 53: 1177-1186
- Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.Science. 2016; 351: 285-289
- Silencing of Agamma-globin gene expression during adult definitive erythropoiesis mediated by GATA-1-FOG-1-Mi2 complex binding at the -566 GATA site.Mol Cell Biol. 2008; 28: 3101-3113
- p66Alpha-MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2-NuRD complex.Proc Natl Acad Sci U S A. 2011; 108: 7487-7492
- Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis.Nat Genet. 2019; 51: 1149-1159
- ZNF410 represses fetal globin by singular control of CHD4.Nat Genet. 2021; 53: 719-728
- ZNF410 uniquely activates the NuRD component CHD4 to silence fetal hemoglobin expression.Mol Cell. 2021; 81: 239-254.e8
- KLF1 regulates BCL11A expression and γ- to β-globin gene switching.Nat Genet. 2010; 42: 742-744
- Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin.Nat Genet. 2010; 42: 801-805
- KLF1 mutations are relatively more common in a thalassemia endemic region and ameliorate the severity of β-thalassemia.Blood. 2014; 124: 803-811
- Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants.Blood. 2016; 127: 1856-1862
- The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans.Blood. 2007; 110: 3624-3626
- Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults.Proc Natl Acad Sci U S A. 2007; 104: 11346-11351
- MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13.Proc Natl Acad Sci U S A. 2011; 108: 1519-1524
- Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells.Nat Genet. 2022; 54: 874-884
- The α-thalassemias.N Engl J Med. 2014; 371: 1908-1916
- The molecular basis of α-thalassemia.Cold Spring Harb Perspect Med. 2013; 3: a011718
- Molecular basis of α-thalassemia.Blood Cells Mol Dis. 2018; 70: 43-53
- Long-range regulation of alpha globin gene expression during erythropoiesis.Curr Opin Hematol. 2008; 15: 176-183
- Novel large deletions in the human α-globin gene cluster: clarifying the HS-40 long-range regulatory role in the native chromosome environment.Blood Cells Mol Dis. 2010; 45: 147-153
- Homozygous deletion of the major alpha-globin regulatory element (MCS-R2) responsible for a severe case of hemoglobin H disease.Blood. 2010; 116: 2193-2194
- A novel selective deletion of the major α-globin regulatory element (MCS-R2) causing α-thalassaemia.Br J Haematol. 2017; 176: 984-986
- Non-deletional alpha thalassaemia: a review.Orphanet J Rare Dis. 2020; 15: 166
- Unstable and thalassemic alpha chain hemoglobin variants: a cause of Hb H disease and thalassemia intermedia.Hemoglobin. 2008; 32: 327-349
- Hemoglobin constant spring, and unusual alpha-chain variant involved in the etiology of hemoglobin H disease.Ann N Y Acad Sci. 1974; 232: 168-178
- The unusual pathobiology of hemoglobin constant spring red blood cells.Blood. 1997; 89: 1762-1769
- Hemoglobin H-constant spring in North America: an alpha thalassemia with frequent complications.Am J Hematol. 2009; 84: 759-761
- Alpha thalassaemia-mental retardation, X linked.Orphanet J Rare Dis. 2006; 1: 15
- The chromatin remodeller ATRX: a repeat offender in human disease.Trends Biochem Sci. 2013; 38: 461-466
- The chromatin remodeller ATRX facilitates diverse nuclear processes, in a stochastic manner, in both heterochromatin and euchromatin.Nat Commun. 2022; 13: 3485
- The alpha-thalassemia/mental retardation syndromes.Medicine. 1996; 75: 45-52
- Refinement of the genetic cause of ATR-16.Hum Genet. 2007; 122: 283-292
- hydrops foetalis syndrome: a case report and review of literature.Br J Haematol. 2001; 115: 72-78
- Heterogeneity of hemoglobin H disease in childhood.N Engl J Med. 2011; 364: 710-718
- An international registry of survivors with Hb Bart’s hydrops fetalis syndrome.Blood. 2017; 129: 1251-1259
- Consensus statement for the perinatal management of patients with α thalassemia major.Blood Adv. 2021; 5: 5636-5639
- Potential new approaches to the management of the Hb Bart’s hydrops fetalis syndrome: the most severe form of α-thalassemia.Hematol Am Soc Hematol Educ Program. 2018; 2018: 353-360
- Reversal of lethal alpha- and beta-thalassemias in mice by expression of human embryonic globins.Blood. 1998; 92: 3057-3063
- Reactivation of a developmentally silenced embryonic globin gene.Nat Commun. 2021; 12: 4439
- Proportion of hemoglobin G Philadelphia (alpha 268 Asn leads to Lys beta 2) in heterozygotes is determined by alpha-globin gene deletions.Proc Natl Acad Sci U S A. 1980; 77: 6874-6878
- Acquired alpha-thalassemia in association with myelodysplastic syndrome and other hematologic malignancies.Blood. 2005; 105: 443-452
- β-thalassemias.N Engl J Med. 2021; 384: 727-743
- Molecular basis of β thalassemia and potential therapeutic targets.Blood Cells Mol Dis. 2018; 70: 54-65
- The molecular basis of β-thalassemia.Cold Spring Harb Perspect Med. 2013; 3: a011700
- Levels of Hb A2 in heterozygotes and homozygotes for beta-thalassemia mutations: influence of mutations in the CACCC and ATAAA motifs of the beta-globin gene promoter.Acta Haematol. 1997; 98: 187-194
- Disrupting the adult globin promoter alleviates promoter competition and reactivates fetal globin gene expression.Blood. 2022; 139: 2107-2118
- Phenotype-genotype relationships in monogenic disease: lessons from the thalassaemias.Nat Rev Genet. 2001; 2: 245-255
- Abnormal RNA processing due to the exon mutation of beta E-globin gene.Nature. 1982; 300: 768-769
- The hemoglobin E thalassemias.Cold Spring Harb Perspect Med. 2012; 2: a011734
- Population and genetic studies suggest a single origin for the Indian deletion beta thalassaemia.Br J Haematol. 1984; 57: 271-278
- Heterogeneity of DNA deletion in gamma delta beta-thalassemia.J Clin Invest. 1981; 67: 878-884
- The molecular basis of β thalassemia, δβ thalassemia, and hereditary persistence of fetal hemoglobin.in: Steinberg M.H. Forget B.G. Higgs D.R. Weatherall D.R. Disorders of hemoglobin: genetics, pathophysiology, and clinical management. Cambridge University Press, Cambridge, UK2009: 323-356
- Molecular basis of hereditary persistence of fetal hemoglobin.Ann N Y Acad Sci. 1998; 850: 38-44
- The fusion of two peptide chains in hemoglobin Lepore and its interpretation as a genetic deletion.Proc Natl Acad Sci U S A. 1962; 48: 1880-1886
- Hemoglobins Lepore and anti-Lepore.Hemoglobin. 1978; 2: 197-233
- Molecular basis for dominantly inherited inclusion body beta-thalassemia.Proc Natl Acad Sci U S A. 1990; 87: 3924-3928
- Is it dominantly inherited beta thalassaemia or just a beta-chain variant that is highly unstable?.Br J Haematol. 1999; 107: 12-21
- Mutations in the general transcription factor TFIIH result in β-thalassaemia in individuals with trichothiodystrophy.Hum Mol Genet. 2001; 10: 2797-2802
- X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction.Blood. 2002; 100: 2040-2045
- KLF1 gene mutations cause borderline HbA(2).Blood. 2011; 118: 4454-4458
- A new gene associated with a β-thalassemia phenotype: the observation of variants in SUPT5H.Blood. 2020; 136: 1789-1793
- A novel mechanism for thalassaemia intermedia.Lancet. 2002; 359: 132-133
- Somatic deletion of the normal beta-globin gene leading to thalassaemia intermedia in heterozygous beta-thalassaemic patients.Br J Haematol. 2004; 127: 604-606
- {beta}-thalassemia major evolution from {beta}-thalassemia minor is associated with paternal uniparental isodisomy of chromosome 11p15.Haematologica. 2008; 93: 913-916
- Myelodysplastic syndrome associated acquired beta thalassemia: “BTMDS”.Am J Hematol. 2016; 91: E325-E327
- The mechanism of formation, structure and physiological relevance of covalent hemoglobin attachment to the erythrocyte membrane.Free Radic Biol Med. 2017; 103: 95-106
- Pathophysiology of beta thalassemia–a guide to molecular therapies.Hematol Am Soc Hematol Educ Program. 2005; 2005: 31-37
- Beta-thalassemia: from genotype to phenotype.Haematologica. 2011; 96: 1573-1575
- Genetic association studies in β-hemoglobinopathies.Hematol Am Soc Hematol Educ Program. 2013; 2013: 354-361
- Controlling alpha-globin: a review of alpha-globin expression and its impact on beta-thalassemia.Haematologica. 2008; 93: 1868-1876
- α-Globin as a molecular target in the treatment of β-thalassemia.Blood. 2015; 125: 3694-3701
- An A gamma type of nondeletional hereditary persistence of fetal hemoglobin with a T–--C mutation at position -175 to the cap site of the A gamma globin gene.Blood. 1989; 73: 329-333
- The T–--C substitution at -198 of the A gamma-globin gene associated with the British form of HPFH generates overlapping recognition sites for two DNA-binding proteins.Nucleic Acids Res. 1990; 18: 5685-5693
- Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin.Nat Commun. 2015; 6: 7085
- KLF1 drives the expression of fetal hemoglobin in British HPFH.Blood. 2017; 130: 803-807
- A natural regulatory mutation in the proximal promoter elevates fetal globin expression by creating a de novo GATA1 site.Blood. 2019; 133: 852-856
- Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin.Elife. 2022; 11: e65421
- Hemoglobin Kenya, the product of fusion of amd polypeptide chains.Arch Biochem Biophys. 1972; 153: 850-853
- Hemoglobin Kenya, the product of a gamma-beta fusion gene: studies of the family.Am J Hum Genet. 1973; 25: 548-563
- The genetic basis of asymptomatic codon 8 frame-shift (HBB:c25_26delAA) β(0) -thalassaemia homozygotes.Br J Haematol. 2016; 172: 958-965
- Cholelithiasis in thalassemia major.Eur J Haematol. 2009; 82: 22-25
- H63D mutation in the HFE gene increases iron overload in beta-thalassemia carriers.Haematologica. 2002; 87: 242-245
- Genome sequencing elucidates Sardinian genetic architecture and augments association analyses for lipid and blood inflammatory markers.Nat Genet. 2015; 47: 1272-1281
- Exome-wide association study of plasma lipids in >300,000 individuals.Nat Genet. 2017; 49: 1758-1766
- Impact of β-thalassemia trait carrier state on inflammatory status in patients with newly diagnosed hypertension.J Cardiovasc Med. 2019; 20: 284-289
- Sickle cell disease.Nat Rev Dis Primers. 2018; 4: 18010
- Overview of compound sickle cell syndromes.(Available at:) (Accessed October 3, 2022)
- Concurrent sickle-cell anemia and alpha-thalassemia: effect on severity of anemia.N Engl J Med. 1982; 306: 270-274
- Paradoxical increase of painful crises in sickle cell patients with alpha-thalassemia.Blood. 1995; 86: 4382
- Genomic polymorphisms in sickle cell disease: implications for clinical diversity and treatment.Expert Rev Hematol. 2010; 3: 443-458
- Molecular diagnosis of thalassemias and hemoglobinopathies: an ACLPS critical review.Am J Clin Pathol. 2017; 148: 6-15
- Update in laboratory diagnosis of thalassemia.Front Mol Biosci. 2020; 7: 74
- The evolving role of next-generation sequencing in screening and diagnosis of hemoglobinopathies.Front Physiol. 2021; 12: 686689
- Next-generation sequencing improves thalassemia carrier screening among premarital adults in a high prevalence population: the Dai nationality.China Genet Med. 2017; 19: 1022-1031
- Next-generation sequencing improves molecular epidemiological characterization of thalassemia in Chenzhou Region, P.R. China.J Clin Lab Anal. 2019; 33: e22845
- ACOG committee on obstetrics. ACOG practice bulletin No. 78: hemoglobinopathies in pregnancy.Obstet Gynecol. 2007; 109: 229-237
- Committee opinion No. 691: carrier screening for genetic conditions.Obstet Gynecol. 2017; 129: e41-e55
- First and second level haemoglobinopathies diagnosis: best practices of the Italian Society of Thalassemia and Haemoglobinopathies (SITE).J Clin Med Res. 2022; 11: 5426
- Prenatal screening and testing for hemoglobinopathy.(Available at:) (Accessed October 3, 2022)
- Non-invasive prenatal diagnosis and screening for monogenic disorders.Eur J Obstet Gynecol Reprod Biol. 2020; 253: 320-327
- Committee opinion No. 690: carrier screening in the age of genomic medicine.Obstet Gynecol. 2017; 129: e35-e40
- Hematopoietic stem-cell transplantation.N Engl J Med. 2006; 354: 1813-1826
- HLA match likelihoods for hematopoietic stem-cell grafts in the U.S. registry.N Engl J Med. 2014; 371: 339-348
- Hemopoietic stem cell transplantation in thalassemia: a report from the European Society for Blood and Bone Marrow Transplantation Hemoglobinopathy Registry, 2000-2010.Bone Marrow Transplant. 2016; 51: 536-541
- Related and unrelated donor transplantation for β-thalassemia major: results of an international survey.Blood Adv. 2019; 3: 2562-2570
- Gene therapy targeting haematopoietic stem cells for inherited diseases: progress and challenges.Nat Rev Drug Discov. 2019; 18: 447-462
- Gene therapy using haematopoietic stem and progenitor cells.Nat Rev Genet. 2021; 22: 216-234
- Editing outside the body: Ex vivo gene-modification for β-hemoglobinopathy cellular therapy.Mol Ther. 2021; 29: 3163-3178
- Research. ZYNTEGLO. U.S. Food and Drug Administration.(Available at:) (Accessed September 21, 2022)
- Betibeglogene Autotemcel gene therapy for Non-β0/β0 genotype β-thalassemia.N Engl J Med. 2022; 386: 415-427
- Gene therapy for β-hemoglobinopathies.Mol Ther. 2017; 25: 1142-1154
- Gene therapy for hemoglobinopathies: beta-thalassemia, sickle cell disease.Hematol Oncol Clin North Am. 2022; 36: 769-795
- In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector.Science. 1996; 272: 263-267
- Gene therapy in patients with transfusion-dependent β-thalassemia.N Engl J Med. 2018; 378: 1479-1493
- Intrabone hematopoietic stem cell gene therapy for adult and pediatric patients affected by transfusion-dependent ß-thalassemia.Nat Med. 2019; 25: 234-241
- Biologic and clinical efficacy of LentiGlobin for sickle cell disease.N Engl J Med. 2022; 386: 617-628
- Post-transcriptional genetic silencing of BCL11A to treat sickle cell disease.N Engl J Med. 2021; 384: 205-215
- Development of a double shmiR lentivirus effectively targeting both BCL11A and ZNF410 for enhanced induction of fetal hemoglobin to treat β-hemoglobinopathies.Mol Ther. 2022; 30: 2693-2708
- 2021 update on clinical trials in β-thalassemia.Am J Hematol. 2021; 96: 1518-1531
- Genome editing approaches to β-hemoglobinopathies.Prog Mol Biol Transl Sci. 2021; 182: 153-183
- Genome editing with CRISPR-Cas nucleases, base editors, transposases and prime editors.Nat Biotechnol. 2020; 38: 824-844
- BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis.Nature. 2015; 527: 192-197
- Long-term engraftment and fetal globin induction upon BCL11A gene editing in bone-marrow-derived CD34+ hematopoietic stem and progenitor cells.Mol Ther Methods Clin Dev. 2017; 4: 137-148
- Induction of fetal hemoglobin synthesis by CRISPR/Cas9-mediated editing of the human β-globin locus.Blood. 2018; 131: 1960-1973
- Highly efficient therapeutic gene editing of human hematopoietic stem cells.Nat Med. 2019; 25: 776-783
- Genome editing of HBG1 and HBG2 to induce fetal hemoglobin.Blood Adv. 2019; 3: 3379-3392
- Homology-driven genome editing in hematopoietic stem and progenitor cells using ZFN mRNA and AAV6 donors.Nat Biotechnol. 2015; 33: 1256-1263
- Gene replacement of α-globin with β-globin restores hemoglobin balance in β-thalassemia-derived hematopoietic stem and progenitor cells.Nat Med. 2021; 27: 677-687
- Correction of β-thalassemia by CRISPR/Cas9 editing of the α-globin locus in human hematopoietic stem cells.Blood Adv. 2021; 5: 1137-1153
- CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia.N Engl J Med. 2021; 384: 252-260
- Efficacy and safety of a single dose of CTX011 for transfusion-dependent beta-thalassemia and severe sickle cell disease. In: European Hematology Association.(Available at:) (Accessed September 21, 2022)
- CRISPR-Cas9-mediated gene editing of the BCL11A enhancer for pediatric β0/β0 transfusion-dependent β-thalassemia.Nat Med. 2022; 28: 1573-1580
- Base editing: advances and therapeutic opportunities.Nat Rev Drug Discov. 2020; 19: 839-859
- Therapeutic base editing of human hematopoietic stem cells.Nat Med. 2020; 26: 535-541
- Programmable C: G to G: C genome editing with CRISPR-Cas9-directed base excision repair proteins.Nat Commun. 2021; 12: 1384
- CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells.Nat Biotechnol. 2021; 39: 41-46
- Glycosylase base editors enable C-to-A and C-to-G base changes.Nat Biotechnol. 2021; 39: 35-40
- Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning.Nat Biotechnol. 2021; 39: 1414-1425
- Correction of beta-thalassemia IVS-II-654 mutation in a mouse model using prime editing.Int J Mol Sci. 2022; 23: 5948
- High-level correction of the sickle mutation is amplified in vivo during erythroid differentiation.iScience. 2022; 25: 104374
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