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Preface| Volume 37, ISSUE 1, Pxiii-xvi, February 2023

Escalation, De-escalation, Adaptation, Speciation, Customization: The New Approaches to Breast Cancer

DOI:https://doi.org/10.1016/j.hoc.2022.08.020
Escalation, De-escalation, Adaptation, Speciation, Customization: The New Approaches to Breast Cancer
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      Harold J. Burstein, MD, PhD, Editor
      Our approaches to breast cancer treatment have undergone a radical transformation over the past 20 years. Catalysts for this transformation include advances in tumor genetics and genomics that have allowed us to effectively define unique subsets or species of breast cancers, both for research purposes and for tailoring individual treatment plans; the development of far more effective targeted therapies, most notably HER2-directed targeted therapies, that have altered the natural history of the disease; and the integration of true multidisciplinary care, where there is an adaptive interplay between stage, local-regional treatments (surgery and radiation), and the likelihood of response to systemic therapy.
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      DOI: https://doi.org/10.1016/j.hoc.2022.08.020

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