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Review Article| Volume 34, ISSUE 1, P127-142, February 2020

Hematologic Malignancies

Published:October 28, 2019DOI:https://doi.org/10.1016/j.hoc.2019.08.020

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      References

        • Eich H.T.
        • Diehl V.
        • Gorgen H.
        • et al.
        Intensified chemotherapy and dose-reduced involved-field radiotherapy in patients with early unfavorable Hodgkin's lymphoma: final analysis of the German Hodgkin Study Group HD11 trial.
        J Clin Oncol. 2010; 28: 4199-4206
        • Engert A.
        • Plütschow A.
        • Eich H.T.
        • et al.
        Reduced treatment intensity in patients with early-stage Hodgkin’s lymphoma.
        N Engl J Med. 2010; 363: 640-652
        • Sasse S.
        • Brockelmann P.J.
        • Goergen H.
        • et al.
        Long-term follow-up of contemporary treatment in early-stage hodgkin lymphoma: updated analyses of the German Hodgkin Study Group HD7, HD8, HD10, and HD11 Trials.
        J Clin Oncol. 2017; 35: 1999-2007
        • Thomas J.
        • Ferme C.
        • Noordijk E.M.
        • et al.
        Comparison of 36 Gy, 20 Gy, or no radiation therapy after 6 cycles of EBVP chemotherapy and complete remission in early-stage Hodgkin lymphoma without risk factors: results of the EORT-GELA H9-F Intergroup Randomized Trial.
        Int J Radiat Oncol Biol Phys. 2018; 100: 1133-1145
        • Radford J.
        • Illidge T.
        • Counsell N.
        • et al.
        Results of a trial of PET-directed therapy for early-stage Hodgkin's lymphoma.
        N Engl J Med. 2015; 372: 1598-1607
        • Andre M.P.E.
        • Girinsky T.
        • Federico M.
        • et al.
        Early positron emission tomography response-adapted treatment in stage I and II Hodgkin lymphoma: final results of the randomized EORTC/LYSA/FIL H10 trial.
        J Clin Oncol. 2017; 35: 1786-1794
        • Fuchs M.
        • Goergen H.
        • Kobe C.
        • et al.
        PET-guided treatment of early-stage favorable Hodgkin lymphoma: final results of the International, Randomized Phase 3 Trial HD16 By the German Hodgkin Study Group.
        Blood. 2018; 132: 925
        • Maraldo M.V.
        • Aznar M.C.
        • Vogelius I.R.
        • et al.
        Involved node radiation therapy: an effective alternative in early-stage hodgkin lymphoma.
        Int J Radiat Oncol Biol Phys. 2013; 85: 1057-1065
        • Specht L.
        • Yahalom J.
        • Illidge T.
        • et al.
        Modern radiation therapy for Hodgkin lymphoma: field and dose guidelines from the International Lymphoma Radiation Oncology Group (ILROG).
        Int J Radiat Oncol Biol Phys. 2014; 89: 854-862
        • Borchmann P.
        • Haverkamp H.
        • Diehl V.
        • et al.
        Eight cycles of escalated-dose BEACOPP compared with four cycles of escalated-dose BEACOPP followed by four cycles of baseline-dose BEACOPP with or without radiotherapy in patients with advanced-stage hodgkin's lymphoma: final analysis of the HD12 trial of the German Hodgkin Study Group.
        J Clin Oncol. 2011; 29: 4234-4242
        • Kreissl S.
        • von Tresckow BG H.
        • Haverkamp H.
        • et al.
        BEACOPP-escalated followed by radiotherapy of initial bulk or residual disease in advanced stage Hodgkin lymphoma: long-term follow up of the HD9 and HD12 trials of the German Hodgkin Study Group.
        Blood. 2016; 128: 923
        • Engert A.
        • Haverkamp H.
        • Kobe C.
        • et al.
        Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin's lymphoma (HD15 trial): a randomised, open-label, phase 3 non-inferiority trial.
        Lancet. 2012; 379: 1791-1799
        • Johnson P.
        • Federico M.
        • Kirkwood A.
        • et al.
        Adapted treatment guided by interim PET-CT scan in advanced Hodgkin's lymphoma.
        N Engl J Med. 2016; 374: 2419-2429
        • Gallamini A.
        • Tarella C.
        • Viviani S.
        • et al.
        Early chemotherapy intensification with escalated BEACOPP in patients with advanced-stage hodgkin lymphoma with a positive interim positron emission tomography/computed tomography scan after two ABVD cycles: long-term results of the GITIL/FIL HD 0607 trial.
        J Clin Oncol. 2018; 36: 454-462
        • Hartmann S.
        • Eichenauer D.A.
        • Plutschow A.
        • et al.
        Histopathological features and their prognostic impact in nodular lymphocyte-predominant Hodgkin lymphoma--a matched pair analysis from the German Hodgkin Study Group (GHSG).
        Br J Haematol. 2014; 167: 238-242
        • King M.T.
        • Donaldson S.S.
        • Link M.P.
        • et al.
        Management of nodular lymphocyte predominant Hodgkin lymphoma in the modern era.
        Int J Radiat Oncol Biol Phys. 2015; 92: 67-75
        • Lazarovici J.
        • Dartigues P.
        • Brice P.
        • et al.
        Nodular lymphocyte predominant Hodgkin lymphoma: a Lymphoma Study Association retrospective study.
        Haematologica. 2015; 100: 1579-1586
        • Chen R.C.
        • Chin M.S.
        • Ng A.K.
        • et al.
        Early-stage, lymphocyte-predominant Hodgkin's lymphoma: patient outcomes from a large, single-institution series with long follow-up.
        J Clin Oncol. 2010; 28: 136-141
        • Horning S.J.
        • Weller E.
        • Kim K.
        • et al.
        Chemotherapy with or without radiotherapy in limited-stage diffuse aggressive non-Hodgkin's lymphoma: Eastern Cooperative Oncology Group study 1484.
        J Clin Oncol. 2004; 22: 3032-3038
        • Reyes F.
        • Lepage E.
        • Munck J.
        • et al.
        Chemotherapy alone with the ACVBP regimen is superior to three cycles of CHOP plus radiotherapy for treatment of low risk localized aggressive lymphoma: the LNH93-1 GELA study.
        Blood. 2003; 100: 93a
        • Bonnet C.
        • Fillet G.
        • Mounier N.
        • et al.
        CHOP alone compared with CHOP plus radiotherapy for localized aggressive lymphoma in elderly patients: a study by the Groupe d'Etude des Lymphomes de l'Adulte.
        J Clin Oncol. 2007; 25: 787-792
        • Miller T.P.
        • Dahlberg S.
        • Cassady J.R.
        • et al.
        Chemotherapy alone compared with chemotherapy plus radiotherapy for localized intermediate- and high-grade non-Hodgkin's lymphoma.
        N Engl J Med. 1998; 339: 21-26
        • Stephens D.M.
        • Li H.
        • LeBlanc M.L.
        • et al.
        Continued risk of relapse independent of treatment modality in limited-stage diffuse large B-cell lymphoma: final and long-term analysis of Southwest Oncology Group Study S8736.
        J Clin Oncol. 2016; 34: 2997-3004
        • Pinnix C.C.
        • Andraos T.Y.
        • Dabaja B.
        • et al.
        Diffuse large B-cell lymphoma in very elderly patients over 80 years old: incorporating consolidative radiation therapy into management decisions.
        Adv Radiat Oncol. 2017; 2: 370-380
        • Odejide O.O.
        • Cronin A.M.
        • Davidoff A.J.
        • et al.
        Limited stage diffuse large B-cell lymphoma: comparative effectiveness of treatment strategies in a large cohort of elderly patients.
        Leuk Lymphoma. 2015; 56: 716-724
        • Held G.
        • Zeynalova S.
        • Murawski N.
        • et al.
        Impact of rituximab and radiotherapy on outcome of patients with aggressive B-cell lymphoma and skeletal involvement.
        J Clin Oncol. 2013; 31: 4115-4122
        • Held G.
        • Murawski N.
        • Ziepert M.
        • et al.
        Role of radiotherapy to bulky disease in elderly patients with aggressive B-cell lymphoma.
        J Clin Oncol. 2014; 32: 1112-1118
        • Pfreundschuh M.
        • Murawski N.
        • Ziepert M.
        • et al.
        Radiotherapy to bulky and extralymphatic disease in combination with 6×R-CHOP-14 or R-CHOP-21 in young good-prognosis DLBCL patients: results of the 2×2 randomized UNFOLDER trial of the DSHNHL/GLA.
        J Clin Oncol. 2018; 36 ([abstract: 7574])
        • Lamy T.
        • Damaj G.
        • Soubeyran P.
        • et al.
        R-CHOP 14 with or without radiotherapy in nonbulky limited-stage diffuse large B-cell lymphoma.
        Blood. 2018; 131: 174-181
        • Lowry L.
        • Smith P.
        • Qian W.
        • et al.
        Reduced dose radiotherapy for local control in non-Hodgkin lymphoma: a randomised phase III trial.
        Radiother Oncol. 2011; 100: 86-92
        • Campbell B.A.
        • Connors J.M.
        • Gascoyne R.D.
        • et al.
        Limited-stage diffuse large B-cell lymphoma treated with abbreviated systemic therapy and consolidation radiotherapy: involved-field versus involved-node radiotherapy.
        Cancer. 2012; 118: 4156-4165
        • Verhappen M.H.
        • Poortmans P.M.
        • Raaijmakers E.
        • et al.
        Reduction of the treated volume to involved node radiation therapy as part of combined modality treatment for early stage aggressive non-Hodgkin's lymphoma.
        Radiother Oncol. 2013; 109: 133-139
        • Yahalom J.
        • Illidge T.
        • Specht L.
        • et al.
        Modern radiation therapy for extranodal lymphomas: field and dose guidelines from the International Lymphoma Radiation Oncology Group.
        Int J Radiat Oncol Biol Phys. 2015; 92: 11-31
        • Illidge T.
        • Specht L.
        • Yahalom J.
        • et al.
        Modern radiation therapy for nodal non-Hodgkin lymphoma-target definition and dose guidelines from the International Lymphoma Radiation Oncology Group.
        Int J Radiat Oncol Biol Phys. 2014; 89: 49-58
        • Brady J.L.
        • Binkley M.S.
        • Hajj C.
        • et al.
        Definitive radiotherapy for localized follicular lymphoma staged by (18)F-FDG PET-CT: a collaborative study by ILROG.
        Blood. 2019; 133: 237-245
        • Binkley M.S.
        • Brady J.L.
        • Hajj C.
        • et al.
        Salvage treatment and survival for relapsed follicular lymphoma following primary radiation therapy: a collaborative study on behalf of ILROG.
        Int J Radiat Oncol Biol Phys. 2019; 104: 522-529
        • Campbell B.A.
        • Voss N.
        • Woods R.
        • et al.
        Long-term outcomes for patients with limited stage follicular lymphoma: involved regional radiotherapy versus involved node radiotherapy.
        Cancer. 2010; 116: 3797-3806
        • Ruella M.
        • Filippi A.R.
        • Bruna R.
        • et al.
        Addition of rituximab to involved-field radiation therapy prolongs progression-free survival in stage I-II follicular lymphoma: results of a multicenter study.
        Int J Radiat Oncol Biol Phys. 2016; 94: 783-791
        • MacManus M.
        • Fisher R.
        • Roos D.
        • et al.
        Randomized trial of systemic therapy after involved-field radiotherapy in patients with early-stage follicular lymphoma: TROG 99.03.
        J Clin Oncol. 2018; 36: 2918-2925
        • Martin N.E.
        • Ng A.K.
        Good things come in small packages: low-dose radiation as palliation for indolent non-Hodgkin lymphomas.
        Leuk Lymphoma. 2009; 50: 1765-1772
        • Ganem G.
        • Lambin P.
        • Socie G.
        • et al.
        Potential role for low dose limited-field radiation therapy (2 x 2 grays) in advanced low-grade non-Hodgkin's lymphomas.
        Hematol Oncol. 1994; 12: 1-8
        • Girinsky T.
        • Guillot-Vals D.
        • Koscielny S.
        • et al.
        A high and sustained response rate in refractory or relapsing low-grade lymphoma masses after low-dose radiation: analysis of predictive parameters of response to treatment.
        Int J Radiat Oncol Biol Phys. 2001; 51: 148-155
        • Haas R.L.
        • Poortmans P.
        • de Jong D.
        • et al.
        High response rates and lasting remissions after low-dose involved field radiotherapy in indolent lymphomas.
        J Clin Oncol. 2003; 21: 2474-2480
        • Sawyer E.J.
        • Timothy A.R.
        Low dose palliative radiotherapy in low grade non-Hodgkin's lymphoma.
        Radiother Oncol. 1997; 42: 49-51
        • Luthy S.K.
        • Ng A.K.
        • Silver B.
        • et al.
        Response to low-dose involved-field radiotherapy in patients with non-Hodgkin's lymphoma.
        Ann Oncol. 2008; 19: 2043-2047
        • Russo A.L.
        • Chen Y.H.
        • Martin N.E.
        • et al.
        Low-dose involved-field radiation in the treatment of non-hodgkin lymphoma: predictors of response and treatment failure.
        Int J Radiat Oncol Biol Phys. 2013; 86: 121-127
        • Hoskin P.J.
        • Kirkwood A.A.
        • Popova B.
        • et al.
        4 Gy versus 24 Gy radiotherapy for patients with indolent lymphoma (FORT): a randomised phase 3 non-inferiority trial.
        Lancet Oncol. 2014; 15: 457-463
        • Schechter N.R.
        • Portlock C.S.
        • Yahalom J.
        Treatment of mucosa-associated lymphoid tissue lymphoma of the stomach with radiation alone.
        J Clin Oncol. 1998; 16: 1916-1921
        • Pinnix C.C.
        • Gunther J.R.
        • Milgrom S.A.
        • et al.
        Outcomes after reduced-dose intensity modulated radiation therapy for gastric mucosa-associated lymphoid tissue (MALT) lymphoma.
        Int J Radiat Oncol Biol Phys. 2019; 104: 447-455
        • Goda J.S.
        • Massey C.
        • Kuruvilla J.
        • et al.
        Role of salvage radiation therapy for patients with relapsed or refractory hodgkin lymphoma who failed autologous stem cell transplant.
        Int J Radiat Oncol Biol Phys. 2012; 84: e329-e335
        • Hiniker S.M.
        • Agarwal R.
        • Modlin L.A.
        • et al.
        Survival and neurocognitive outcomes after cranial or craniospinal irradiation plus total-body irradiation before stem cell transplantation in pediatric leukemia patients with central nervous system involvement.
        Int J Radiat Oncol Biol Phys. 2014; 89: 67-74
        • Pinnix C.C.
        • Yahalom J.
        • Specht L.
        • et al.
        Radiation in central nervous system leukemia: guidelines from the International Lymphoma Radiation Oncology Group.
        Int J Radiat Oncol Biol Phys. 2018; 102: 53-58
        • Bakst R.L.
        • Tallman M.S.
        • Douer D.
        • et al.
        How I treat extramedullary acute myeloid leukemia.
        Blood. 2011; 118: 3785-3793
        • Bakst R.L.
        • Dabaja B.S.
        • Specht L.K.
        • et al.
        Use of radiation in extramedullary leukemia/chloroma: guidelines from the International Lymphoma Radiation Oncology Group.
        Int J Radiat Oncol Biol Phys. 2018; 102: 314-319
        • Tsang R.W.
        • Campbell B.A.
        • Goda J.S.
        • et al.
        Radiation therapy for solitary plasmacytoma and multiple myeloma: guidelines from the International Lymphoma Radiation Oncology Group.
        Int J Radiat Oncol Biol Phys. 2018; 101: 794-808
        • Wax M.K.
        • Yun K.J.
        • Omar R.A.
        Extramedullary plasmacytomas of the head and neck.
        Otolaryngol Head Neck Surg. 1993; 109: 877-885
        • Liebross R.H.
        • Ha C.S.
        • Cox J.D.
        • et al.
        Clinical course of solitary extramedullary plasmacytoma.
        Radiother Oncol. 1999; 52: 245-249
        • Michalaki V.J.
        • Hall J.
        • Henk J.M.
        • et al.
        Definitive radiotherapy for extramedullary plasmacytomas of the head and neck.
        Br J Radiol. 2003; 76: 738-741
        • Dagan R.
        • Morris C.G.
        • Kirwan J.
        • et al.
        Solitary plasmacytoma.
        Am J Clin Oncol. 2009; 32: 612-617
        • Ozsahin M.
        • Tsang R.W.
        • Poortmans P.
        • et al.
        Outcomes and patterns of failure in solitary plasmacytoma: a multicenter Rare Cancer Network study of 258 patients.
        Int J Radiat Oncol Biol Phys. 2006; 64: 210-217
        • Tseng Y.D.
        • Cutter D.J.
        • Plastaras J.P.
        • et al.
        Evidence-based review on the use of proton therapy in lymphoma from the Particle Therapy Cooperative Group (PTCOG) Lymphoma Subcommittee.
        Int J Radiat Oncol Biol Phys. 2017; 99: 825-842
        • Denniston K.A.
        • Verma V.
        • Bhirud A.R.
        • et al.
        Effect of akimbo versus raised arm positioning on breast and cardiopulmonary dosimetry in pediatric Hodgkin lymphoma.
        Front Oncol. 2016; 6: 176
        • Aznar M.C.
        • Maraldo M.V.
        • Schut D.A.
        • et al.
        Minimizing late effects for patients with mediastinal Hodgkin lymphoma: deep inspiration breath-hold, IMRT, or both?.
        Int J Radiat Oncol Biol Phys. 2015; 92: 169-174
        • Paumier A.
        • Ghalibafian M.
        • Gilmore J.
        • et al.
        Dosimetric benefits of intensity-modulated radiotherapy combined with the deep-inspiration breath-hold technique in patients with mediastinal Hodgkin's lymphoma.
        Int J Radiat Oncol Biol Phys. 2012; 82: 1522-1527
        • Rechner L.A.
        • Maraldo M.V.
        • Vogelius I.R.
        • et al.
        Life years lost attributable to late effects after radiotherapy for early stage Hodgkin lymphoma: the impact of proton therapy and/or deep inspiration breath hold.
        Radiother Oncol. 2017; 125: 41-47
        • Taylor P.A.
        • Kry S.F.
        • Followill D.S.
        Pencil beam algorithms are unsuitable for proton dose calculations in lung.
        Int J Radiat Oncol Biol Phys. 2017; 99: 750-756
        • Paganetti H.
        • Niemierko A.
        • Ancukiewicz M.
        • et al.
        Relative biological effectiveness (RBE) values for proton beam therapy.
        Int J Radiat Oncol Biol Phys. 2002; 53: 407-421
        • Fiandra C.
        • Filippi A.R.
        • Catuzzo P.
        • et al.
        Different IMRT solutions vs. 3D-conformal radiotherapy in early stage Hodgkin’s lymphoma: dosimetric comparison and clinical considerations.
        Radiat Oncol. 2012; 7: 186
        • Voong K.R.
        • McSpadden K.
        • Pinnix C.C.
        • et al.
        Dosimetric advantages of a “butterfly” technique for intensity-modulated radiation therapy for young female patients with mediastinal Hodgkin’s lymphoma.
        Radiat Oncol. 2014; 9: 94
        • Starke A.
        • Bowden J.
        • Lynn R.
        • et al.
        Comparison of butterfly volumetric modulated arc therapy to full arc with or without deep inspiration breath hold for the treatment of mediastinal lymphoma.
        Radiother Oncol. 2018; 129: 449-455
        • Everett A.
        • Flampouri S.
        • Louis D.
        • et al.
        Comparison of radiation techniques in lower mediastinal lymphoma.
        Int J Radiat Oncol Biol Phys. 2018; 102: S190-S191
        • Dabaja B.S.
        • Hoppe B.S.
        • Plastaras J.P.
        • et al.
        Proton therapy for adults with mediastinal lymphomas: the International Lymphoma Radiation Oncology Group guidelines.
        Blood. 2018; 132: 1635
        • Gunther J.R.
        • Rahman A.R.
        • Dong W.
        • et al.
        Craniospinal irradiation prior to stem cell transplant for hematologic malignancies with CNS involvement: effectiveness and toxicity after photon or proton treatment.
        Pract Radiat Oncol. 2017; 7: e401-e408
        • Feng M.
        • Moran J.H.
        • Koeling T.
        • et al.
        Int J Radiat Oncol Biol Phys. 2011; 79: 10-18