Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.
Content published before 2002 is available via pay-per-view purchase only.
Subscribe:
Subscribe to Hematology/Oncology ClinicsAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Cancer facts & figures.American Cancer Society, Atlanta (GA)2013 (Available at:)
- Cancer facts & figures.American Cancer Society, Atlanta (GA)2015 (Available at:)
- Genetic predisposition to colorectal cancer.Nat Rev Cancer. 2004; 4: 769-780
- Genetic epidemiology of cancer: from families to heritable genes.Int J Cancer. 2004; 111: 944-950
- Models of genetic susceptibility to breast cancer.Oncogene. 2006; 25: 5898-5905
- Cancer of the pancreas in two brothers and one sister.Int J Pancreatol. 1987; 2: 383-391
- Pancreatic carcinoma in brothers.Ann Intern Med. 1982; 97: 282
- Adenocarcinoma of the pancreas in four siblings.Gastroenterology. 1973; 65: 137-139
- Familial carcinoma of the pancreas.Clin Genet. 1976; 9: 463-469
- Familial pancreatic adenocarcinoma in three generations. A case report and a review of the literature.Cancer. 1987; 59: 1661-1664
- Life-style risk factors for pancreatic cancer in Louisiana: a case–control study.Am J Epidemiol. 1988; 128: 324-336
- Risk of pancreatic cancer among individuals with a family history of cancer of the pancreas.Int J Cancer. 2002; 97: 807-810
- Family history and the risk of liver, gallbladder, and pancreatic cancer.Cancer Epidemiol Biomarkers Prev. 1994; 3: 209-212
- Diabetes mellitus, other medical conditions and familial history of cancer as risk factors for pancreatic cancer.Br J Cancer. 1999; 80: 1830-1837
- Epidemiology of pancreatic cancer in Japan: a nested case-control study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC).Int J Epidemiol. 2003; 32: 257-262
- Familial risk of pancreatic cancer.J Natl Cancer Inst. 2001; 93: 640-644
- Risk factors for pancreatic cancer: case-control stud.Am J Gastroenterol. 2007; 102: 2696-2707
- Family history of diabetes and pancreatic cancer as risk factors for pancreatic cancer: the PACIFIC study.Cancer Epidemiol Biomarkers Prev. 2013; 22: 1913-1917
- Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).Int J Cancer. 2010; 127: 1421-1428
- A population-based description of familial clustering of pancreatic cancer.Clin Gastroenterol Hepatol. 2010; 8: 812-816
- Risk of malignancy in first-degree relatives of patients with pancreatic carcinoma.Cancer. 2005; 104: 388-394
- Family history is a significant risk factor for pancreatic cancer: results from a systematic review and meta-analysis.Fam Cancer. 2009; 8: 109-117
- Pancreatic cancer genetic epidemiology consortium.Cancer Epidemiol Biomarkers Prev. 2006; 15: 704-710
- Clinical and pathologic features of familial pancreatic cancer.Cancer. 2014; 120: 3669-3675
- Environmental and heritable factors in the causation of cancer–analyses of cohorts of twins from Sweden, Denmark, and Finland.N Engl J Med. 2000; 343: 78-85
- Evidence for a major gene influencing risk of pancreatic cancer.Genet Epidemiol. 2002; 23: 133-149
- Inheritance of pancreatic cancer in pancreatic cancer-prone families.Med Clin North Am. 2000; 84 (x–xi): 677-690
- Genetics of cancer of the pancreas: from genes to families.in: Pitt H.A. Surgical oncology clinics of North America, vol. 7, No. 1, pancreatic cancer. W. B. Saunders, New York1998: 1-23
- Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds.Cancer Res. 2004; 64: 2634-2638
National Cancer Institute Surveillance, Epidemiology, and End Results Program. Available at: http://seer.cancer.gov/. Accessed May 22, 2015.
- Familial pancreatic cancer: a review.Semin Oncol. 1996; 23: 251-275
- Genetic susceptibility to pancreatic cancer.Mol Carcinog. 2012; 51: 14-24
- ATM mutations in patients with hereditary pancreatic cancer.Cancer Discov. 2012; 2: 41-46
- Prevalence of germline mutations in cancer predisposition genes in patients with pancreatic cancer.Gastroenterology. 2014; 148: 556-564
- The incidence of pancreatic cancer in BRCA1 and BRCA2 mutation carriers.Br J Cancer. 2012; 107: 2005-2009
- BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer (FPC): a PACGENE study.Genet Med. 2014; https://doi.org/10.1038/gim.2014.153
- Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene.Science. 2009; 324: 217
- A new susceptibility locus for autosomal dominant pancreatic cancer maps to chromosome 4q32-34.Am J Hum Genet. 2002; 70: 1044-1048
- Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism.PLoS Med. 2006; 3: e516
- Absence of deleterious palladin mutations in patients with familial pancreatic cancer.Cancer Epidemiol Biomarkers Prev. 2009; 18: 1328-1330
- Fanconi anemia gene mutations in young-onset pancreatic cancer.Cancer Res. 2003; 63: 2585-2588
- The genetics of FANCC and FANCG in familial pancreatic cancer.Cancer Biol Ther. 2004; 3: 167-169
- Germ line Fanconi anemia complementation group C mutations and pancreatic cancer.Cancer Res. 2005; 65: 383-386
- Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations and risk for pancreatic adenocarcinoma.Cancer. 2010; 116: 203-209
- Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%.Cancer Res. 2002; 62: 3789-3793
- The prevalence of BRCA2 mutations in familial pancreatic cancer.Cancer Epidemiol Biomarkers Prev. 2007; 16: 342-346
- Prevalence of BRCA1 and BRCA2 mutations in Ashkenazi Jewish families with breast and pancreatic cancer.Cancer. 2012; 118: 493-499
- An emerging entity: pancreatic adenocarcinoma associated with a known BRCA mutation: clinical descriptors, treatment implications, and future directions.Oncologist. 2011; 16: 1397-1402
- Clinical outcomes in pancreatic adenocarcinoma associated with BRCA-2 mutation.Anticancer Drugs. 2015; 26: 224-226
National Institutes of Health. Available at: http://ClinicalTrials.gov. Accessed May 22, 2015.
- Pancreatic cancer screening in a prospective cohort of high-risk patients: a comprehensive strategy of imaging and genetics.Clin Cancer Res. 2010; 16: 5028-5037
- ACG clinical guideline: genetic testing and management of hereditary gastrointestinal cancer syndromes.Am J Gastroenterol. 2015; 110: 223-262
- Familial pancreatic cancer–status quo.Int J Colorectal Dis. 2014; 29: 139-145
- International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer.Gut. 2013; 62: 339-347
- Familial pancreatic cancer–current knowledge.Nat Rev Gastroenterol Hepatol. 2012; 9: 445-453
- Five years of prospective screening of high-risk individuals from families with familial pancreatic cancer.Gut. 2009; 58: 1410-1418
- Screening and surgical outcomes of familial pancreatic cancer.Surg Clin North Am. 2013; 93: 629-645
Article info
Publication history
Published online: June 08, 2015
Footnotes
Disclosures: The author has no conflicts.
Supported in part by National Cancer Institute grants R01 CA97075 and P50 CA102701.
Identification
Copyright
© 2015 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
