Editorial| Volume 25, ISSUE 1, Pxiii, February 2011


      In this issue of Hematology/Oncology Clinics of North America, we are reprinting a selection of articles from three other recent Clinics issues that we think will be of special interest to our readers. This is a “hybrid” issue focusing on Immunodeficiency from two different angles.
      In the first half of the issue, we present a series of articles on bone marrow transplantation for congenital immunodeficiency syndromes. It includes a brief history of bone marrow transplantation, and articles on the full range of alternative stem cell sources for transplantation for this otherwise fatal disorder. We close this part of the issue with an article summarizing the progress in gene therapy for the disease.
      In the second half, we focus on the infectious complications of acquired immunodeficiency associated with stem cell transplantation. There are updates on the natural history of viral, bacterial, and fungal infections that complicate transplantation. In addition, we include a review of the infectious complications of new biologic agents that act to modulate immunity, and a final article focused on immunotherapy and vaccination to prevent posttransplant infections.