In 1978, the term “monoclonal gammopathy of undetermined significance” (MGUS) was
introduced. MGUS is defined as a serum monoclonal (M) protein less than 3.0 g/dL;
less than 10% plasma cells in the bone marrow, if done; little or no M protein in
the urine; and absence of lytic bone lesions, anemia, hypercalcemia or renal insufficiency.
This article discusses the recognition, prevalence, natural history, and progression
of MGUS. Management of the disease is discussed along with its association with other
disorders. Information on smoldering multiple myeloma is included.
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Footnotes
Supported in part by grants CA62242 and CA107476 from the National Cancer Institute.
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© 2007 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
